9P The survival effect and prognostic factors of residual tumor confined to the uterus after radical radio-chemotherapy in cervical cancer

Detection of residual tumor after radio-chemotherapy (RCX) in patients with locally advanced cervical cancer creates problems clinical management. The aim study is to evaluate the survival effect and prognostic importance limited uterus who received primary RCX. 125 cases inoperable cervix applied our clinic between June 2012 December 2018. Patients undergo magnetic resonance imaging pelvis before brachytherapy treatment, positron emulsion tomography (PET-CT) treatment response at 6 months radical treatment. median age was 50 111 (88.8%) were diagnosed squamous cell carcinoma 14 (11.2%) adenocarcinoma. Median size 5 cm 71 stage IIB (56.8%), lymphnodes (LN) detected PET-CT 70 patients. Residual found 47 (37.6%) follow-up external RCX 45 (7-91), 10 months. Three-year overall (OS), local recurrence-free (LRFS), distant metastasis-free (DMFS) rates 86.9%, 89.1%, 76.4%, respectively. In univariate analysis, it seen that presence an unfavorable factor on LRFS (p=0.01), OS (p=0.001), DMFS (p=0.01). Pre-treatment evaluation, pelvic LN (p=0.05) detection radiotherapy (p=0.015) factors DMFS. Local control (LC) better < 60 years metastases more common tumors > (p=0.02). LC <60 Presence determined multivariate analysis as important LRFS. Treatment controversial Survival worse 6-month follow-ups need for adjuvant therapy should be considered these